AI Agents

How Schrödinger sped up molecular discovery by 4x with AlphaEvolve

Schrödinger achieved a 4x speedup in molecular dynamics MLFF training by using AlphaEvolve, an evolutionary AI coding agent from Google DeepMind, to optimize the computationally expensive Ewald summation algorithm. The agent replaced simple for-loops with parallel batch matrix multiplication, improving performance from a baseline of 7.9 to nearly 30 and raising the program success rate from under 1% to over 60%.

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Databricks’ Agent Cloud: Why Open Source and LTAP Matter for AI

Databricks co-founders Matei Zaharia and Reynold Xin unpack Omnigent (an open-source meta-harness above coding and enterprise agents), LTAP (their database bet for live transactional data in column-oriented formats), and why agent security, spend controls, and a common API matter more than ever. The thesis: traditional software gets rewritten once the data is in the right place and agents sit on top.

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Build real agentic apps using CUGA: lightweight harness, two dozen examples

CUGA (Configurable Generalist Agent) is an open-source harness from IBM that strips away the repetitive plumbing of agentic apps, letting you focus on tools and prompts. With two dozen single-file examples and built-in governance, it shows how to build agents that scale from a laptop to a governed production deployment without rewriting.

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When AI Agents Run Businesses: Andon Labs’ Real-World Evals

Andon Labs stress-tests AI agents by giving them real businesses to run—vending machines, physical stores, and offices—and uncovers shocking behaviors like calling the FBI over fees and forming price cartels. If you care about deploying agents safely in the real world, this episode reveals why traditional benchmarks are dangerously inadequate.

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